Visual Neuroscience, Mood and Addiction
Department of Medical Neurobiology
Institute for Medical Research, Israel-Canada (IMRIC)
Faculty of Medicine
Hebrew University of Jerusalem, Israel
Who we are
Shai Sabbah, Ph.D.
Principle Investigator
Born in Dimona in southern Israel, I started my academic journey with an undergraduate degree in biology from the Technion – Israel Institute of Technology, Haifa. I went on to the Hebrew University for my master’s degree under the supervision of Prof. Nadav Shashar in the Department of Evolutions, Systematics and Ecology. For my doctorate, I travelled to Queen’s University in Kingston, Ontario, Canada where, under the supervision of Prof. Craig Hawryshyn, I characterized the underwater light environment and explored how evolution has shaped the properties of cone photoreceptors in the vertebrate retina. I employed electrophysiological techniques to assess functional diversity in the visual systems of fish and probed how the visual system changes with development and across habitats. I then took on a postdoctoral research position in the Department of Neuroscience at Brown University, Providence, RI, under the mentorship of Prof. David Berson. My research there focused on (1) image stabilization and the tuning of direction selective cells in the retina, and (2) mechanisms of luminance coding in the retina. In 2018, I returned to the Hebrew University and established my laboratory for Visual Neuroscience, Mood, and Addiction at the Faculty of Medicine.
Email: shai.sabbah@mail.huji.ac.il
Nouran Abed Al-Haq
Elyashiv Zangen
Christopher Lawrence
Hadeel abu-kamel
Noam Chertoff
Noi Cohen
Yedidya Weinberg
Maya Bresler
Mor Hait
What we think we do
Beyond forming images, light provides the brain with continuous information about the external world – signaling safety or threat, shaping alertness and motivation, and influencing how we learn from experience. We study how these variations are transformed by the nervous system into signals that guide emotion, cognition, and motivation.
To address this question, we investigate the structure and function of specific retinal and brain circuits using complementary rodent models, including the nocturnal mouse and the diurnal sand rat. By integrating analyses across multiple levels, we link neural activity to behavior and mental state.
Our work combines anatomical mapping of neural circuits with physiological and functional measurements of neural and neurotransmitter activity, targeted manipulation of defined cell types and pathways, and quantitative behavioral assays to examine how visual and light-related signals are processed in the brain.
In parallel, our human research integrates behavioral measures with functional magnetic resonance imaging (fMRI) to examine how light intensity information influences brain activity in higher-order brain regions.
By bridging animal and human studies, we aim to uncover shared principles by which neural circuits convert visual information into meaningful brain signals that shape behavior and experience across species.
Luminance Encoding in the Human Brain
The prefrontal cortex (PFC) is a central hub for executive control, integrating cognitive, emotional, and motivational processes that support flexible behavior and social interaction. Disruption […]
Light–Mood Networks in Diurnal Mammals
Disrupted lighting – such as excessive nighttime light, irregular schedules, or short winter days – can increase the risk of depression and anxiety, while carefully […]
From Light to Fear: How the Brain Learns Safety
Animals and humans must quickly learn what is dangerous and what is safe in order to survive. This kind of “fear learning” depends on a […]
How Light Supports Focus, Decision-Making, and Mental Readiness
In many real-world settings, people are required to stay alert, make rapid decisions, and maintain focus under challenging conditions such as irregular schedules, fatigue, and […]
Luminance-Dependent Modulation of Retinal Function
The mammalian retina maintains high sensitivity over an extraordinary range of luminance levels, ranging from starlight to bright sunlight. This is achieved by switching between […]
Direction selectivity in the retina and brain
Visual motion tells us how objects are moving in the world, and how we are moving within that world. Our work has recently transformed the […]
What we really do
Where the magic happens
Lab news
Open positions
We are currently recruiting highly motivated candidates for M.Sc. and Ph.D. studies
Successful candidates will show solid communication skills in English, ability to work both independently and as part of a research team, strong scientific motivation, and skill in data processing. Experience in one or more of the following would be an advantage: intracranial surgeries, optogenetics, animal behavioral analysis, two-photon imaging, whole-cell and in vivo electrophysiology, and Matlab or python programing.
An application package, including a motivation letter, curriculum vitae, and names of 2-3 referees, should be sent to Dr. Shai Sabbah shai.sabbah@mail.huji.ac.il.
